On November 8, 2010, Deadline reported that Irish stage actress/director Fiona Shaw (best known in the United States for her role as Aunt Petunia in the Harry Potter films) had been cast as Marnie, an insecure and timid palm reader who is possessed by the spirit of a powerful witch. Former Dexter star Courtney Ford has been cast in the recurring role of Portia Bellefleur, sister to Andy. Actor Dane DeHaan (In Treatment) has also been cast as Timbo.

On November 23, Deadline reported that actress Jessica Tuck, who portrays vampire spokesperson Nan Flannigan, will be promoted to series regular starting this season. Three new female cast members were announced: Janina Gavankar (The L Word, The Gates) will play a public school teacher named Luna, who is also a shapeshifter; Alexandra Breckenridge (Life Unexpected, Family Guy) will play a wiccan named Daisy; and relative newcomer Vedette Lim will play Naomi, a fierce cage fighter.[13] Daniel Buran will play Raoul, the pack master of the Shreveport werewolves and Alcide's superior and, as in the previous season, Allan Hyde will reprise his role as Godric. Gary Cole (Office Space, Harvey Birdman: Attorney at Law) will play Earl Stackhouse